TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
نویسندگان
چکیده
منابع مشابه
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.
The cytokines RANKL and TNF activate NF-κB signaling in osteoclast precursors (OCPs) to induce osteoclast (OC) formation. Conversely, TNF can limit OC formation through NF-κB p100, which acts as an inhibitor, and TNF receptor-associated receptor 3 (TRAF3); however, a role for TRAF3 in RANKL-mediated OC formation is unknown. We found that TRAF3 limits RANKL-induced osteoclastogenesis by suppress...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10677-0